Low-Dose Naltrexone (LDN)
starting at $79/mo
FSA/HSA eligible
Free shipping
Flex dose tablets
Low-Dose Naltrexone (LDN) briefly blocks opioid receptors, leading to a rebound increase in the body’s natural endorphins. This effect helps modulate the immune system and reduce inflammation. It can also help with appetite control.
Potential Benefits
Reduce inflammation
Weight loss and appetite control
Regulate Immune system
May be helpful with Hashimoto’s, Rheumatoid Arthritis, Lupus
May be helpful with Crohn’s and Ulcerative Colitis
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Naltrexone HCl
30 day suppy
If approved, appropriate dose will be determined by a licensed healthcare provider during your complimentary online exam.
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Low-Dose Naltrexone (LDN) works by briefly blocking the body’s opioid receptors. This triggers your body to release endorphins. That boost in endorphins sets off several helpful processes:
• Immune support: Helps balance immune activity and reduce overactive inflammatory responses
• Anti-inflammatory effects: Lowers cytokines and NF-κB signaling, which are linked to chronic inflammation
• Metabolic support: May improve insulin sensitivity and reduce inflammatory signaling in immune cells
• Appetite regulation: Supports natural appetite control by increasing α-MSH activity, which helps decrease hunger and increase energy use
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What is Low-Dose Naltrexone (LDN)?
Low-Dose Naltrexone is a lower dose of naltrexone that may be prescribed off-label to support immune balance and inflammation regulation. Your provider will determine if LDN is appropriate for your health goals.How do LDN Flex-Dose Tablets work?
The LDN flex-dose tablet is designed for easy and precise dosing. The tablet is scored into quarters (¼). It does not require a pill cutter. Place the tablet on a solid surface with the scored side up and firmly press down on the middle of the tablet—it will easily break into quarters.What are the ingredients in LDN Flex-Dose Tablets?
Active ingredient: Naltrexone
Inactive ingredient: Prebiotic filler
Suitable for vegetarians and vegans.How should LDN be titrated?
LDN is titrated differently for each individual depending on the purpose. Please follow your provider’s instructions for titrating LDN.What should I do if I miss a dose?
There is no need to make up a missed dose of LDN. Simply resume your regular dosing schedule.Should LDN be cycled?
There is no need to cycle LDN. LDN has a short half-life of 4 to 6 hours.Can LDN be stopped abruptly?
Yes. There is no harm in stopping LDN abruptly. It does not cause withdrawal effects and does not need to be tapered down.Who should NOT use LDN?
Please refer to the medication information linked on this page. Make sure to discuss your current medications and health history with your provider to determine if LDN is appropriate for you.
Disclaimer: Products are only available if prescribed after an online consultation with a licensed healthcare provider. Compounded medications are dispensed by third-party USA licensed pharmacies. The Food and Drug Administration does not review compounded medications for safety or effectiveness and the statements on this page have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent diseases. Results may vary. Discontinue use and seek care if you if you experience any adverse reaction to this product. Product is offered by subscription which you can cancel anytime. Photo is for illustration purposes; actual packaging may differ.
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LDN Benefits
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![A person wearing a cap, black t-shirt, and purple leggings jumps with arms outstretched in a mountainous landscape with lush green hills and a winding river.]()
Reduces Inflammation
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![Person wearing a beige jacket eating a salad at a restaurant table with a glass of white wine, a flower in a vase, and bread on the table.]()
Appetite Control
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![Person silhouetted against the sunset, balancing on a rock with arms outstretched and one leg raised.]()
Immune Regulation
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![Close-up of a woman wearing a white crop top and high-waisted denim shorts, standing with hands on hips, with blue chairs in the background.]()
Weight Management
Less inflammation, more lift.
LDN
Calmer systems, lighter you.
Chronic inflammation can make everything feel harder—including managing your weight. LDN can help.
Immune system balance
Calm inflammation
Promote weight loss
Available in:
Flex dose tablets: daily, easy titration
High-level care, wherever you are.
24/7 Online provider support
Manage treatments online
Free delivery to your door
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How Birdie Online Works
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Step 1
HEALTH QUESTIONNAIRE
Complete a no-obligation form online about your health history and goals for treatment.
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Step 2
COMPLIMENTARY EVALUALTION
Meet with a licensed healthcare provider 100% online to see if you qualify for a treatment plan.
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Step 3
FAST & FREE SHIPPING
If approved, your prescription will ship directly to you. Get regular online check-ins and support.
High Standards. High Quality.
Birdie partners with licensed pharmacies to provide lab-tested, quality medications.
Compounded in the U.S.A.
Third-party tested for quality control
Popular Products
Designed to elevate.
Grounded in research.
Research is our passion- check out some articles about LDN:
de Carvalho, J. F., & Skare, T. (2023). Low-dose naltrexone in rheumatological diseases. Mediterranean Journal of Rheumatology, 34(1), 1–6. https://doi.org/10.31138/mjr.34.1.1
Li, Z., You, Y., Griffin, N., Feng, J., & Shan, F. (2018). Low-dose naltrexone (LDN): A promising treatment in immune-related diseases and cancer therapy. International Immunopharmacology, 61, 178–184. https://doi.org/10.1016/j.intimp.2018.05.020
Patten, D. K., Schultz, B. G., & Berlau, D. J. (2018). The safety and efficacy of low-dose naltrexone in the management of chronic pain and inflammation in multiple sclerosis, fibromyalgia, Crohn’s disease, and other chronic pain disorders. Pharmacotherapy, 38(3), 382–389. https://doi.org/10.1002/phar.2086
Younger, J., Parkitny, L., & McLain, D. (2014). The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain. Clinical Rheumatology, 33(4), 451–459.